Tag Archives: Science Magazine
TOP JOURNALS: RESEARCH HIGHLIGHTS FROM SCIENCE MAGAZINE (FEB 5, 2021)
This week, Science celebrates the impending 20th anniversary of the publication of the draft human genome sequence—a landmark achievement by any measure…The Human Genome Project (HGP) was an internationally supported public project (Celera Genomics was the private effort that simultaneously sequenced the human genome). When the endeavor was launched in 1990, collaboration among a diverse group of scientists was essential because the sequencing was distributed across a number of international research sites.
The American Association for the Advancement of Science (AAAS, the publisher of Science) also looks forward to next week’s annual meeting, whose theme is “Understanding Dynamic Ecosystems.” At first glance, these two events may seem unrelated. But the successful completion of the human genome sequence ushered in biology’s era of “big science” and created a research ecosystem for tackling complex, technology-driven, and data-intensive multidisciplinary projects that continue to improve our understanding of cancer, the microbiome, the brain, and other areas of biology.
The Human Genome Project (HGP) was an internationally supported public project (Celera Genomics was the private effort that simultaneously sequenced the human genome). When the endeavor was launched in 1990, collaboration among a diverse group of scientists was essential because the sequencing was distributed across a number of international research sites. High-throughput technologies for DNA sequencing were critical to the project’s success, and the participation of biotech companies in the effort was instrumental in driving down the cost, speed, and throughput of generating DNA sequence. The ever-increasing amount of sequence data drove the development of mathematical and computational tools for assembling and annotating the data. Neither the laboratory scientists nor the computational scientists could have done this alone, and the convergence of these disciplines has been one of the most important legacies of the early genome efforts. There was also a commitment to train the next generation of genome scientists, and over the past 20 years, many colleges and universities have established new undergraduate and graduate programs in quantitative and systems biology. Life sciences students today graduate with a very different set of skills than they did in 2000.
Science Podcast: Human Genome Sequencing – 20 Years Of Research & Data
This week we’re dedicating the whole show to the 20th anniversary of the publication of the human genome. Today, about 30 million people have had their genomes sequenced. This remarkable progress has brought with it issues of data sharing, privacy, and inequality.
Host Sarah Crespi spoke with a number of researchers about the state of genome science, starting with Yaniv Erlich, from the Efi Arazi School of Computer Science and CEO of Eleven Biotherapeutics, who talks about privacy in the age of easily obtainable genomes. Next up Charles Rotimi, director of the Center for Research on Genomics and Global Health at the National Human Genome Research Institute, discusses diversity—or lack thereof—in the field and what it means for the kinds of research that happens. Finally, Dorothy Roberts, professor in the departments of Africana studies and sociology and the law school at the University of Pennsylvania, talks about the seemingly never-ending project of disentangling race and genomes.
Covid-19: ‘How Do The Leading Vaccines Work?’
As countries like the United States and United Kingdom inoculate their residents with never-before used vaccine technology, others, including Russia, China, and India, are investing in more traditional approaches, like inactivated coronavirus vaccines. But no matter the technique, together they have the potential to create multiple lines of defense against SARS-CoV-2. Science senior correspondent Jon Cohen explains how each of these vaccines can protect us from severe illness—and what understanding the details of our immune responses could mean for the future of human trials.
TOP JOURNALS: RESEARCH HIGHLIGHTS FROM SCIENCE MAGAZINE (JAN 29, 2021)
Science Podcast: Social Costs Of Carbon & The Chirps Of Mole-Rats
On its first day, the new Biden administration announced plans to recalculate the social cost of carbon—a way of estimating the economic toll of greenhouse gases. Staff Writer Paul Voosen and host Sarah Crespi discuss why this value is so important and how it will be determined.
Next up, Alison Barker, a postdoctoral researcher at the Max Delbrück Center for Molecular Medicine, talks with Sarah about the sounds of naked mole-rats. You may already know naked mole-rats are pain and cancer resistant—but did you know these eusocial mammals make little chirps to identify themselves as colony members? Can these learned local dialects make naked mole-rats a new research model for language learning?
TOP JOURNALS: RESEARCH HIGHLIGHTS FROM SCIENCE MAGAZINE (JAN 22, 2021)
Science Podcast: Rodents In Research, Gut Allergic Reactions & Cobra Venom
Online News Editor David Grimm joins host Sarah Crespi to discuss a controversial new paper that estimates how many rodents are used in research in the United States each year.
Though there is no official number, the paper suggests there might be more than 100 million rats and mice housed in research facilities in the country—doubling or even tripling some earlier estimates.
Next, Staff Writer Jennifer Couzin-Frankel talks with Sarah about a new theory behind the cause of irritable bowel syndrome—that it might be a localized allergic reaction in the gut. Sarah also chats with Taline Kazandjian, a postdoctoral research associate at the Centre for Snakebite Research & Interventions in Liverpool, U.K., about how the venom from spitting cobras has evolved to cause maximum pain and why these snakes might have developed the same defense mechanism three different times.
TOP JOURNALS: RESEARCH HIGHLIGHTS FROM SCIENCE MAGAZINE (JAN 15, 2021)
Science Podcast: Aracibo Observatory Research, Environment & Behavior
Science Senior Correspondent Daniel Clery regales host Sarah Crespi with tales about the most important work to come from 57 years of research at the now-defunct Arecibo Observatory and plans for the future of the site.
Sarah also talks with Toman Barsbai, an associate professor in the school of economics at the University of Bristol, about the influence of ecology on human behavior—can we figure out how many of our behaviors are related to the different environments where we live? Barsbai and colleagues took on this question by comparing behaviors around finding food, reproduction, and social hierarchy in three groups of animals living in the same places: foraging humans, nonhuman mammals, and birds.
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