The strong inverse correlation between lifespan and mutation rate: we accrue mutations at a slower pace than many mammals but have roughly the same number of mutations by the end of our respective lifespans https://t.co/MBgFMkEeUn@Naturepic.twitter.com/H9kXAXXwjs
Cells acquire mutations throughout life, a process that is known to give rise to cancer and has been proposed to contribute to ageing. There is little knowledge, however, about the rate at which mutations accumulate in species other than humans, and whether this rate is influenced by biological traits such as lifespan or body size. In this week’s issue, Alex Cagan, Adrian Baez-Ortega and colleagues address these questions. The researchers studied the speed at which mutations accumulate during life in 16 mammalian species and found that the number of mutations increases by a roughly constant amount each year. They also observed that the molecular processes causing mutations are broadly similar across species. Crucially, the team identified a strong anticorrelation between lifespan and mutation rate: longer-lived species accrue mutations at a slower pace than shorter-lived ones, such that different species have roughly the same number of mutations by the end of their respective lifespans.
On this week’s show: Climate change is killing critical soil organisms in arid regions, and early evidence for the Maya calendar from a site in Guatemala.
Staff Writer Elizabeth Pennisi joins host Sarah Crespi to discuss how climate change is affecting “biocrust,” a thin layer of fungi, lichens, and other microbes that sits on top of desert soil, helping retain water and create nutrients for rest of the ecosystem. Recent measurements in Utah suggest the warming climate is causing a decline in the lichen component of biocrust, which is important for adding nitrogen into soils.
Next, Sarah talks with Skidmore College anthropologist Heather Hurst, who directs Guatemala’s San Bartolo-Xultun Regional Archaeological Project, and David Stuart, a professor of art history and director of the Mesoamerica Center at the University of Texas, Austin, about their new Science Advances paper. The study used radiocarbon dating to pin down the age of one of the earliest pieces of the Maya calendar. Found in an archaeological dig in San Bartolo, Guatemala, the character known as “seven deer” (which represents a day in the Maya calendar), was dated to 300 B.C.E. That early appearance challenges what researchers know about the age and origins of the Maya dating system.
A new study used a light-based tomographic #3Dprinting approach to synthesize fine glass parts. The method should be flexible enough to provide a variety of high-quality glass parts for various applications.
COVER – A glass structure about 4.5 mm tall with features as small as 0.25 mm is 3D printed with microscale computed axial lithography followed by high-temperature sintering. The process enables the synthesis of highly transparent and inert glass parts with fine details, which are useful for a variety of applications.
For biologists, a long-standing question has been why some animals live longer than others. This week a team have attempted to answer this, by measuring the rates that different animal species accumulate mutations. They show that longer-lived animals acquire mutations at a slower rate, which helps to explain why cancer risk does not scale with lifespan.
07:56 Research Highlights
A clinical trial suggests a change to the treatment of a pregnancy ailment, and astronomers identify the largest known structure produced by a single galaxy.
10:43 The war in Ukraine’s effects on global energy
Many European countries are dependent on Russian fossil fuels for energy production. Following Russia’s unprovoked invasion of Ukraine, these countries are looking to wean themselves off these fuels, which could have short- and long-term impacts on emissions and food production.
19:58 A new measurement of a particle’s mass hints at new physics
Last week, a new estimate of the W boson’s mass caused much excitement among physicists. The result suggests that this particle is heavier than theory predicts, a finding that could be the first major breach in the standard model of particle physics. However, measuring W bosons is notoriously tricky, and further work will be needed to confirm the finding.
In Nature this week: Climate pledges – fully realizing current promises could limit warming to just below 2 °C , but 1.5 °C is still out of reach. Browse the full issue here: https://t.co/eEMf9XL8lBpic.twitter.com/GuaC5pdolG
No human has set foot on the Moon for decades. But an armada of exciting new missions are set to explore the lunar surface once more.
The DNA detective
The consumer genetic testing kits hitting the shelves have allowed scientists to piece together our family trees better than ever before. Geneticist Prof Turi King tells us more.
Fit to burst
Inflation is a pretty useful tool in nature. Zoologist Jules Howard takes a closer look at some of the incredible animals that can blow themselves up like balloons.
The Hitchhiker’s Guide to the Metaverse
What is the metaverse, can anyone visit, and where’s the best place to go?
Even before COVID-19 increased the risks of cognitive impairments, it had been estimated that 152.8 million people globally would be living with dementia by 2050. Yet treatment for Alzheimer’s disease has hardly improved since it was discovered in 1901, notes neurologist and dementia specialist Sara Manning Peskin. Now, most clinical trials tackling dementia are “deeply rooted in molecular data”. Peskin’s powerful study — immersed in her patients’ stories — analyses neurology’s attempt to reach oncology’s molecular understanding.
The Insect Crisis
Oliver Milman Atlantic (2022)
Insect decline is obvious — but hard to quantify. Environmental journalist Oliver Milman suggests a drop of more than 90% in some places, in his vivid alarm call. The causes are unclear, but include habitat destruction by intensive farming, pesticide use and climate change. Insects’ “intricate dance” with Earth’s environment makes them crucial to human food supplies. We should learn to eat them, not meat, suggests Milman: that will help to save them by freeing farmland from crops needed to feed livestock.
Insulin — The Crooked Timber
Kersten T. Hall Oxford Univ. Press (2022)
Insulin was first used to treat human diabetes 100 years ago, after it was isolated by two medical scientists in 1921. Historian of science Kersten Hall describes this transformative event, together with insulin’s development as the first drug produced by genetic engineering and its lucrative exploitation — using a blend of profound research, lively writing and personal knowledge of diabetes. He argues that the history is a tale not of geniuses or saints, but rather one of “monstrous egos, toxic insecurities and bitter career rivalry”.
How to Solve a Crime
Angela Gallop Hodder & Stoughton (2022)
More than a century ago, criminologist Edmond Locard established forensic science on the principle that “every contact leaves a trace”. The field’s current sophistication and contribution to justice would be beyond his “wildest imaginings”, writes forensic scientist Angela Gallop. She tells gripping stories from her own and others’ experience, beginning with thirteenth-century Chinese investigator Sung Tz’u. He identified a farmer’s killer by asking fellow villagers to put their sickles on the ground; flies alighted on one blade bearing traces of blood.
The Sloth Lemur’s Song
Alison Richard William Collins (2022)
Anthropologist and conservationist Alison Richard has been absorbed by Madagascar for half a century. She writes that the country’s “animals and plants offer a wonderful array of rabbit holes down which a person fascinated by the natural world could disappear for a lifetime”. Why, for example, does its largest lemur sing spellbindingly across the treetops with its mate for many minutes? And what environmental conditions created the island’s unique — now disastrously threatened —
On this week’s show: A new measurement of the W boson could challenge physicists’ standard model, and an abundance of marine RNA viruses.
Staff Writer Adrian Cho joins host Sarah Crespi to discuss a new threat to the standard model of particle physics—a heavier than expected measurement of a fundamental particle called the W boson. They chat about how this measurement was taken, and what it means if it is right.
Next, Sarah talks about the microscopic denizens of Earth’s oceans with Ahmed Zayed, a research scientist in the department of microbiology at Ohio State University, Columbus. They talk about findings from a global survey of marine RNA viruses. The results double the number of known RNA viruses, suggesting new classifications will be needed to categorize all this viral diversity.
News, Views and Reviews For The Intellectually Curious
Boomers Daily 