Science Magazine – March 17, 2023 issue: An alpine newt (Ichthyosaura alpestris) walks to a breeding pond in the Alps, France. Many amphibians have a cryptic upper side but a normally concealed, conspicuous underside. These hidden signals have evolved for several reasons, including as a warning display to would-be predators.

STRAIGHT FROM THE HEART

Conceptual illustration: a giant heart opens up on a hinge to reveal several gauges. Three of them, labeled HDL, LDL, and ApoB, display low levels. One, labeled Ceramides, displays high levels and is vibrating and letting off steam. Three tiny scientists stand at the foot of the heart, and one shines a flashlight on the Ceramides gauge.

Lipids called ceramides may be better predictors of cardiovascular problems than cholesterol. Doctors and pharma are waking up to their potential

Bacteria require phase separation for fitness in the mammalian gut

The gut microbiota is critical for human health. Understanding how beneficial bacteria colonize the gut enables medical interventions that promote gut health. Krypotou et al. discovered a mechanism that enhances the fitness of a commensal bacterium in the gut.