Tag Archives: Genes

Cover Preview: Nature Magazine – March 17, 2022

Volume 603 Issue 7901, 17 March 2022

Volume 603 Issue 7901

For more than 50 years, scientists have been trying to understand the relationship between DNA sequence, gene-expression phenotype and fitness to decipher principles of gene regulatory evolution. In this week’s issue, Eeshit Dhaval Vaishnav, Carl de Boer, Aviv Regev and their colleagues present a framework for understanding and engineering regulatory DNA sequences that takes a step towards this goal. The researchers built this framework around an ‘oracle’ they developed using a deep neural network model that predicts gene expression given a promoter DNA sequence. The neural network was trained using the expression measurements for tens of millions of promoter sequences. The result was an AI oracle that predicts expression from sequence well enough to study the evolutionary history and future evolvability of regulatory DNA sequences, as well as to design regulatory DNA sequences for synthetic biology applications. The cover offers a visual representation of the evolutionary properties of sequences at the extremes of the evolvability spectrum. 

Science: Tonga Volcanic Eruption, Roaming Genes Of Reindeers, Pterosaurs

Scientists scramble to understand the devastating Tongan volcano eruption, and modelling how societal changes might alter carbon emissions.

In this episode:

00:46 Understanding the Tongan eruption

On the 15th of January, a volcano in the South Pacific Ocean erupted, sending ash into the upper atmosphere, and unleashing a devastating tsunami that destroyed homes on Tonga’s nearby islands. Now scientists are trying to work out exactly what happened during the eruption — and what it means for future volcanic risks.

News Feature: Why the Tongan eruption will go down in the history of volcanology

08:49 Research Highlights

The genes associated with reindeers’ roaming behaviour, and how fossilised puke has thrown up new insights into pterosaurs’ stomachs.

Research Highlight: A reindeer’s yearning to travel can be read in its genes

Research Highlight: Petrified puke shows that ancient winged reptiles purged

11:29 Modelling societal changes to carbon emissions

A team of researchers have modelled what humans might do in the face of climate change, and looked at how societal, political and technological changes could alter future emissions.

Research article: Moore et al.

18:12 Briefing Chat

We discuss some highlights from the Nature Briefing. This time, China alters its guidelines for gene-edited crops, and how Guinea worm infections have been driven down from millions of cases a year to just 14.

Nature News: China’s approval of gene-edited crops energizes researchers

Nature News: Just 14 cases: Guinea worm disease nears eradication

Science: The James Webb Space Telescope Launches, Genes For Long Life Spans

The James Webb Space Telescope was first conceived in the late 1980s. Now, more than 30 years later, it’s finally set to launch in December. 

After such a long a road, anticipation over what the telescope will contribute to astronomy is intense. Daniel Clery, a staff writer for Science, joins host Sarah Crespi to talk about what took so long and what we can expect after launch.

You might have heard that Greenland sharks may live up to 400 years. But did you know that some Pacific rockfish can live to be more than 100? That’s true, even though other rockfish species only live about 10 years. Why such a range in life span? Greg Owens, assistant professor of biology at the University of Victoria, discusses his work looking for genes linked with longer life spans.

Science Podcast: Inside A Proton, Cold Genes & Growing Small Intestines

The surprising structure of protons, and a method for growing small intestines for transplantation.

In this episode:

00:45 Probing the proton’s interior

Although studied for decades, the internal structure of the proton is still throwing up surprises for physicists. This week, a team of researchers report an unexpected imbalance in the antimatter particles that make up the proton.

Research Article: Dove et al.

News and Views: Antimatter in the proton is more down than up

07:08 Research Highlights

How an inactive gene may help keep off the chill, and Cuba’s isolation may have prevented invasive species taking root on the island.

Research Highlight: Impervious to cold? A gene helps people to ward off the chills

Research Highlight: Marauding plants steer clear of a communist-ruled island

09:48 A new way to grow a small intestine

Short Bowel Syndrome is an often fatal condition that results from the removal of the small intestine. Treatment options are limited to transplantation, but donor intestines are hard to come by and can be rejected by the body. Now researchers may have developed a method to grow a replacement small intestine using stem cells and a small section of colon.

Research Article: Sugimoto et al.

15:50 Briefing Chat

We discuss some highlights from the Nature Briefing. This time, the landing of Perseverance on Mars, and the researchers speaking with lucid dreamers.

Nature News: Mars video reveals Perseverance rover’s daring touchdown

Nature News: Touch down! NASA’s Mars landing sparks new era of exploration