Science Magazine | Boomers Daily

We don’t know where consciousness comes from. And we don’t know whether animals have it, or whether we can detect it in patients in comas. Do neuroscientists even know where to look? A new competition aims to narrow down the bewildering number of theories of consciousness and get closer to finding its biological signs by pitting different theories against each other in experimental settings. Freelance journalist Sara Reardon talks with host Sarah Crespi about how the competition will work.

In our second segment, we talk about how we think about children. For thousands of years, adults have complained about their lack of respect, intelligence, and tendency to distraction, compared with previous generations. A new study out this week in Science Advances suggests our own biased childhood memories might be at fault. Sarah Crespi talks with John Protzko of the University of California, Santa Barbara, about how terrible people thought kids were in 3800 B.C.E. and whether understanding those biases might change how people view Generation Z today.

From a Science Magazine online article:

Antibiotic use diminished the gut microbiome composition and impaired the ability of the immune system to generate antibodies. Treatment with antibiotics also disturbed bile acid metabolism and caused inflammatory responses.

From the original findings the Journal “Cell.com”:

Emerging evidence indicates a central role for the microbiome in immunity. However, causal evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy adults prior and subsequent to seasonal influenza vaccination. Despite a 10,000-fold reduction in gut bacterial load and long-lasting diminution in bacterial diversity, antibody responses were not significantly affected. However, in a second trial of subjects with low pre-existing antibody titers, there was significant impairment in H1N1-specific neutralization and binding IgG1 and IgA responses.

In addition, in both studies antibiotics treatment resulted in (1) enhanced inflammatory signatures (including AP-1/NR4A expression), observed previously in the elderly, and increased dendritic cell activation; (2) divergent metabolic trajectories, with a 1,000-fold reduction in serum secondary bile acids, which was highly correlated with AP-1/NR4A signaling and inflammasome activation. Multi-omics integration revealed significant associations between bacterial species and metabolic phenotypes, highlighting a key role for the microbiome in modulating human immunity.