Lively Cannaregio is known for the 16th-century Jewish Ghetto. The Strada Nova is a popular local shopping thoroughfare, and the backstreets are a destination for crafts and vintage goods. Casual canalside restaurants and bars line nearby Fondamenta della Misericordia and Fondamenta dei Ormesini. The stately Ca’ d’Oro palace displays a Renaissance art collection.

The Venetian Ghetto was the area of Venice in which Jews were forced to live by the government of the Venetian Republic. The English word ghetto is derived from the Jewish ghetto in Venice. The Venetian Ghetto was instituted on 29 March 1516. It was not the first time that Jews in Venice were compelled to live in a segregated area of the city. In 1552 Venice had 160,000 inhabitants, including 900 Jews, who were mainly merchants.